Document Type : Research Paper
Authors
1
Department of Pharmacognosy, Nehru College of Pharmacy, Pampady, Thiruvilwamala, Thrissur District, Kerala–680 597, India
2
Periyar College of Pharmaceutical Sciences, Periyar Centenary Educational Complex, K. Sathanoor Main Road, Tiruchirappalli-620021, Tamilnadu, India
Abstract
Canarium L. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. The present study investigeated the invivo anti-inflammatory activity of essential oil obtained by hydrodistillation of resin of Canarium strictum Roxb. In the current study, anti-inflammatory activity of essential oil of Canarium strictum Roxb (10-100 mg/kg) has been established by using the carrageenan (acute inflammation model) and formalin (chronic inflammation model) induced paw edema in mice. The dose dependent activity has been observed, the higher dose 100 mg /kg (p<0.01) exhibited momentous anti-inflammatory activity that was compared with standard drug diclofenac sodium in both acute and chronic inflammatory animal models. The perceived anti-inflammatory activity might be due to inhibition of histamine, serotonin, kinins, substance P, prostaglandins, and bradykinin at the inflammed area. More elaborate investigation is needed to correlate the possible effect of major terpenes on inflammation. Our data recommend that EOCS inhibits the paw edema and granulation tissue in experimental animal models of chronic inflammation, and acute inflammation would be a probable choice for treatment of chronic and acute inflammatory disorders.
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