Biological Evaluation of New oxadiazole-based Synthetic α-glycosidase Inhibitors for Hyperglycemia Management

Document Type : Research Paper

Authors

1 Department of Biology, Damghan Branch, Islamic Azad University

2 bDepartment of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran

4 Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

5 Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

10.22034/ijps.2022.530551.1846

Abstract

The present study was conducted to investigate the hypoglycemic activity of 3,4,5-triphenyl-oxadiazole derivatives
and its effects on liver, lung, and kidney function in streptozotocin (STZ)-induced diabetic rats. For this purpose,
male Wistar rats were divided into four groups (n = 4). Diabetes was induced in four groups by a single dose of STZ
at 65 mg/kg body weight, administrated intraperitoneal. After 28 days of treatment, fasting blood sugar (FBS) levels
and other biochemical parameters such as cholesterol, triglycerides phosphorous, urea creatinine, etc. were measured.
Also, the markers of liver and kidney function, such as urea, serum creatinine, aspartate aminotransferase, alanine
aminotransferase, and gamma-glutamyl transferase levels were determined. The study showed that the 3,4,5-
triphenyl-oxadiazole derivatives at 100 mg/kg body weight had a significant antidiabetic activity after 28 days of
treatment as the FBS levels decreased significantly while the serum insulin levels increased. Moreover, a significant
decrease in the liver and kidney function markers in treated rats indicated the protective effect of the 3,4,5-triphenyloxadiazole derivatives against liver and kidney damage. The serum concentrations were normal in the control and the healthy group treated with these derivatives. The results of this study showed that both derivatives can regulate
hyperglycemia and complications of diabetes.

Keywords