Possible Rapid Therapeutics for SARS Coronavirus 2 RNA-dependent RNA polymerase: A Systematic Review

Document Type : Research Paper


1 Department of Microbiology, Parasitology, and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran.

2 Immunology Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

3 Department of Microbiology and Medical Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

4 School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

5 Deputy of Research & Technology, Ardabil University of Medical Sciences, Ardabil, Iran



Background: Research confirms that viral polymerases play a key role in viral genome replication and transcription. HenceAccordingly, they are essential for the multiplication and survival of viral particles.
Methods: Our reviewThis research attempted to review is limited to the original papers published in the English language from 2019 to 2020 using variousbased on various databases, including PubMed, Scopus, Google Scholar, and Science Direct.
Results: According to 159 reviewed papers, 27 drugs may were identified to effectively prevent RNA-dependent RNA polymerase (RdRp RdRpP), of COVID-19 which , are presented and reviewed in the order of their date of discovery date and paper publication.
?? agreed on the order of drug discovery years and paper publication, respectively.
Conclusion: In this paper, we realized that concerning the structure comparison and sequence alignment, suggest that the mode of substrate RdRP RdRp is is highly conserved in diverse RNA viruses. This finding provides a foundation for designing broad-spectrum antiviral drugs based on nucleotide analogs.


Main Subjects